Phenyl Pyruvic Oligophrenia: Short Review with the Report of an Affected Family
نویسنده
چکیده
Phenyl pyruvic oligophrenia, first described by Foiling (1934), is a well-defined clinical entity associated with an inborn metabolic defect involving the amino-acid phenylalanine. The patient excretes an excessive amount (above 1 gramme per day) of phenyl pyruvic acid and is invariably an idiot or an imbecile. The incidence in general population according to Jervis (Jervis, 1939) is 4 in 100,000. 1 to 2 per cent of all mentally defective persons (Holt and Howland, 1940) and 0.8 per cem of the institutionalized feeble-minded (Penrose, 1946) are suffering from this malady.
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